منابع مشابه
Small mammalian animal models of heart disease.
There is an urgent clinical need to develop new therapeutic approaches for treating cardiovascular disease, but the biology of cardiovascular regeneration is complex. Model systems are required to advance our understanding of the pathogenesis, progression, and mechanisms underlying cardiovascular disease as well as to test therapeutic approaches to regenerate tissue and restore cardiac function...
متن کاملDevelopment of Therapeutics for Heart Failure Small Animal Models of Heart Failure Development of Novel Therapies, Past and Present
The study of heart failure requires viable animal models whereby chronic changes in myocardial structure and function can evolve and the progression of heart failure and left ventricular (LV) dysfunction can be quantified. During the past 40 years, basic and translational scientists have used small animal models to explore the pathophysiology of heart failure and to develop novel therapies that...
متن کاملSmall animal models of heart failure: development of novel therapies, past and present.
The study of heart failure requires viable animal models whereby chronic changes in myocardial structure and function can evolve and the progression of heart failure and left ventricular (LV) dysfunction can be quantified. During the past 40 years, basic and translational scientists have used small animal models to explore the pathophysiology of heart failure and to develop novel therapies that...
متن کاملAnimal models of human cardiovascular disease, heart failure and hypertrophy.
The progress made in our understanding of the pathophysiology and treatment of congestive heart failure (CHF) would not have been possible without a number of animal models of heart failure and hypertrophy, each one having unique advantages as well as disadvantages. The species and interventions used to create CHF depends on the scientific question as well as on factors such as ethical and econ...
متن کاملAnimal models of heart failure with preserved ejection fraction.
Heart failure with preserved ejection fraction (HFpEF) constitutes a clinical syndrome in which the diagnostic criteria of heart failure are not accompanied by gross disturbances of systolic function, as assessed by ejection fraction. In turn, under most circumstances, diastolic function is impaired. Although it now represents over 50 % of all patients with heart failure, the mechanisms of HFpE...
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ژورنال
عنوان ژورنال: Circulation: Heart Failure
سال: 2009
ISSN: 1941-3289,1941-3297
DOI: 10.1161/circheartfailure.108.839761